Dendritic Computation
Neurons must integrate and process information to generate output necessary for behavior. These computations occur primarily along their dendrites. Among the most important aspect of behavior is the ability to adapt in response to experience. Therefore, we are studying dendritic computation in the cerebellum to understand how its neurons encode learning.
Multi-site recording from a Purkinje cell.
In vivo imaging of Purkinje cell dendritic calcium activity.
Measuring in vivo Purkinje cell dendritic calcium activity while optogenetically suppressing climbing fiber input.