Disease Pathophysiology

Cerebellar dysfunction produces movement abnormalities; it may also play a role in autism (ASD) and intellectual disability (ID) because a number of risk factor genes for these disorders are expressed in its tissue. We are studying how the computational capacity of the cerebellum may be compromised in models of ASD and ID. We are also exploring whether the cerebellum may be a therapeutic access point to help ameliorate symptoms associated with these disorders.